Endocrine Abstracts

Aims: Hiponatremia is the most frequent electrolyte disturbance. Our aim is to retrospectively analyze the diagnosis of hyponatremia in the discharge sheets of a tertiary hospital during 5 yearsMethod: Data from the MBDS (Minimum Basic Data Set) of the discharged patients from the Hospital Clínico San Carlos (Madrid) between the years 2005 and 2009 was analysed. The 5th Edition of the ICD-9-CM was used for the codification of the diagnoses and proce...

Angiotensin II (A-II) stimulates aldosterone (aldo) secretion through the zona glomerulosa AT1R. A-II can be metabolized to angiotensin III (A-III) which also stimulates aldo synthesis. In the rat A-III stimulates aldo secretion through the AT2R receptor.The human adrenocortical HAC15 cells were incubated with A-II or A-III (10 nM) for 24 h and the concentration of aldo and cortisol (F) measured in the media. A-II produced a fourfold and A-III a twofold ...

Diagnosis of primary aldosteronism (PA) is made by screening, confirmation testing and subtype diagnosis (CT scan and adrenal vein sampling, AVS). However, some tests are costly and unavailable in most hospitals. We evaluated the role of serum 18-hydroxycorticosterone (s18OHB) and urinary and serum 18-hydroxycortisol (u and s18OHF) and 18-oxocortisol (u and s18oxoF) in the diagnosis of PA and its subtypes, aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (...

Introduction: The contrast agents iopanoic acid and ipodate are potent inhibitors of thyroid function, reducing type I deodinase T3 generation, inhibiting thyroid liberation of T4 and T3, and T3 receptor binding, with off-label use in hyperthyroid emergencies. However, since the interruption of iopanoic acid production this year, neither agent is currently available in Spain.Case report: A 34-year-old male was ...

Background: Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, the identification of novel molecular targets for treatment is urgently needed to improve patients’ outcomes. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative-splicing processes might be used as potential novel therapeutic tools for PCa. In this context, although RBM22 has been id...